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Welcome trog623

Wow you have done your part and it should be corrected, right? Can't add much. Suppose you have reset the PCM by disconnecting the battery. Battery has been checked and is O.K. Fuel pump checked. Could the plug wires have become damaged? One member here suggested cam sensor. Sorry nothing else, not much help. When you figure it out a post from you would be most helpful to the next guy on what corrected you issue. Good Luck.

Universal P0300 Misfire Detected Code Video Some things to look at when a misfire detected code happens

How To Test Fuel Injectors - REAL EASY!!

Trouble shooting a misfire, Code P0300, P0301, P0302, P0303, P0304, P0305, P0306, P0307, P0308 Published on Feb 16, 2014
Misfire Trouble Shooting: 30 to 60 minutes ($50 / $75 / $120)

If your car is running rough at idle or hesitating during acceleration, stalling at idle, there is a good chance that it is misfiring. Most of these car motors function on 100 year old basic principals of a combustion engine. They need the proper mix of AIR, FUEL, SPARK, COMPRESSION and TIMING to operate smoothly, in all of it's cylinders. This video will show and explain how to narrow down your possible problem.
 

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Is that the original battery in your Nitro? They really only last about 3 years. If so put that on your to-do list. Not sure it would cause your issues however. Head replacement is not normal for a Nitro.
 

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If you remember, Rick, there was a post about left hand cylinder head cracking in 2011 3.5 V6 engines. Chrysler will cover under warranty.
Chrysler Group will extend the warranty for consumers who bought certain 2011-13 vehicles with 3.6-liter V-6 Pentastar engines.


Thanks John

John you have a good memory and I remembered it too but did not find it at the time. The problem is that trog623 has a 4.0 engine not the 3.6-liter V-6 Pentastar engine. Do you remember any issues with a Nitro cylinder head? I did do some research "On-line" and remember a Nitro owner having heads replaced but it did not correct his issue.
 

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WOW having had a PO302 error code (#2 cylinder misfire detected) on my 07 Nitro R/T 4.0 engine your issue scares me! I have seen head gasket issues and cam replacements as needed repairs to solve this type of codes. It looks like at least for now I corrected my PO302 error code with a simple additive. Chevron Techron Concentrate Plus Fuel System Cleaner - 20 oz. Maybe in my case it was one dirty spark plug or injector? I'm sure if I drove the Nitro more it would not have been an issue.

My R/T is a very low mileage vehicle but lets face it, it is 12 years old and could use replacement of many of what you have done including spark plug wires. Don't know how long this low cost simple repair will keep working but it will go to the Dealer since I do have a backup "Lifetime Power train Warranty" if maintenance replacement items don't solve any future error codes. No way am I going to try to figure out myself and repair my Nitro when I might end up like you and some others just in case it could be a covered engine issue.

I have no suggestions except bad fuel or spark plug wires and hopefully you will find the cause and report back here so we can share the resolve. GOOD LUCK!
 

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I have a 2010 Caravan with same issue and have checked compression, cylinder leak down check, injector drop test, fuel pressure check, swapped coils plugs and injectors from one side to the other and the misfires are all on 2,4,6 no matter what I do??? Pulling my hair out, WTF
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You have reset your Caravan computer, right? After you ERASE your error code how long before it reappears? What causes it to show again. Idle or driving it?
 
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